id: Pfam:PF04025
pfam_id: PF04025
name: Extracellular matrix regulatory protein A-like
short_name: RemA-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04025
counters:
  proteins: 3892
  matches: 3892
  proteomes: 2354
  taxa: 4062
  structures: 3
  alphafold_models: 2684
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007169
description: This family of mostly uncharacterised proteins includes the extracellular matrix regulatory
  protein A (RemA) from Bacillus subtilis. RemA is required for biosynthesis of the extracellular matrix
  and biofilm formation [[cite:PUB00089811],[cite:PUB00100525]]. It binds to DNA at multiple sites upstream
  of the promoters of the operons eps and tapA-sipW-tasA, which are required for the synthesis of the
  extracellular matrix components, extracellular polysaccharide and TasA amyloid proteins. SinR negatively
  regulates eps operon expression by occluding RemA binding [[cite:PUB00089811]]. Structure of RemA homologue
  from Geobacillus thermodenitrificans revealed that it forms an unique octameric ring with the potential
  to form a 16-meric superstructure and suggests that RemA can wrap DNA around its ring-like structure
  [[cite:PUB00100525]].