id: Pfam:PF04076
pfam_id: PF04076
name: Bacterial OB fold (BOF) protein
short_name: BOF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04076
counters:
  proteins: 2142
  matches: 2146
  proteomes: 1544
  taxa: 2390
  structures: 1
  alphafold_models: 1372
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005220
description: Proteins in this family form an OB-fold. Analysis of the predicted binding site of BOF family
  proteins implies that they lack nucleic acid-binding properties [[cite:PUB00016305]]. They contain an
  predicted N-terminal signal peptide which indicates that they localise in the periplasm where they may
  function to bind proteins, small molecules, or other typical OB-fold ligands [[cite:PUB00016305]]. As
  hypothesised for the distantly related OB-fold containing bacterial enterotoxins, the loss of nucleotide-binding
  function and the rapid evolution of the BOF ligand-binding site may be associated with the presence
  of BOF proteins in mobile genetic elements and their potential role in bacterial pathogenicity [[cite:PUB00016305]].