id: Pfam:PF04168
pfam_id: PF04168
name: A predicted alpha-helical domain with a conserved ER motif.
short_name: Alpha-E
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04168
counters:
  proteins: 10852
  matches: 10891
  proteomes: 7165
  taxa: 10082
  structures: 0
  alphafold_models: 7027
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007296
description: An uncharacterized alpha helical domain containing a highly conserved ER motif and typically
  found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide
  synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily,
  an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal
  to a circularly permuted COOH-NH2 ligase domain [[cite:PUB00057486]].