id: Pfam:PF04175
pfam_id: PF04175
name: Protein of unknown function (DUF406)
short_name: DUF406
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04175
counters:
  proteins: 1083
  matches: 1083
  proteomes: 977
  taxa: 1360
  structures: 3
  alphafold_models: 703
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005272
description: Members of this family appear to be found only in gamma proteobacteria. The function of this
  protein family is undetermined. Solution of the structures of the two members of this family investigated
  bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC.
  Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures
  under study, they do correspond to a surface-region structurally aligned with residues that are highly
  conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly
  constituting a catalytic site of a yet uncharacterised enzyme specific for gamma proteobacteria.