id: Pfam:PF04190
pfam_id: PF04190
name: Golgi to ER traffic protein 4
short_name: GET4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04190
counters:
  proteins: 4116
  matches: 4204
  proteomes: 3267
  taxa: 8653
  structures: 11
  alphafold_models: 3516
  domain_architectures: 66
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007317
description: In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins
  into the endoplasmic reticulum membrane [[cite:PUB00092561],[cite:PUB00092562]]. In humans, Get4 is
  part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble
  state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes
  their sorting to the proteasome where they undergo degradation [[cite:PUB00092560],[cite:PUB00086005],[cite:PUB00086007],[cite:PUB00086008]].
  The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane
  proteins to the endoplasmic reticulum membrane [[cite:PUB00092560],[cite:PUB00086008],[cite:PUB00092563]].