id: Pfam:PF04326
pfam_id: PF04326
name: Schlafen, AlbA_2
short_name: SLFN_AlbA_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04326
counters:
  proteins: 12925
  matches: 12943
  proteomes: 7286
  taxa: 13051
  structures: 31
  alphafold_models: 8752
  domain_architectures: 234
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007421
description: This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important
  in cell differentiation and defense against viruses [[cite:PUB00151569],[cite:PUB00151570]]. This domain
  is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence unique to these
  proteins that may form a dimer interface [[cite:PUB00151569]]. The AlbA_2 domain is RNA-binding and
  RNase region as it contains the highly conserved catalytic glutamic acid residues [[cite:PUB00151569]].