id: Pfam:PF04343
pfam_id: PF04343
name: Domain of unknown function DUF488
short_name: DUF488
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04343
counters:
  proteins: 4633
  matches: 4652
  proteomes: 4007
  taxa: 6608
  structures: 0
  alphafold_models: 2903
  domain_architectures: 25
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007438
description: This entry has been described to include subclades of DUF488 domains (namely DUF488-s, for
  DUF488-short subclade, DUF488-l for long subclade and DUF488-u for DUF488-standalone subclade) which
  all which contain the ancestral core of the domain. DUF488-s commonly pairs with the DUF488-l subclade
  on the genome. In the case of DUF488-l and DUF488-u, the core domain is followed by a single beta-strand
  that stacks at the C-terminus of the core beta-sheet and a multi-helical 'cap' [[cite:PUB00153826]].
  Unlike the DUF488-s and DUF488-l subclades, DUF488-u is not found adjacent to other DUF488 subclades
  on the genome [[cite:PUB00153826]].