id: Pfam:PF04365
pfam_id: PF04365
name: Ribonuclease toxin, BrnT, of type II toxin-antitoxin system
short_name: BrnT_toxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04365
counters:
  proteins: 4523
  matches: 4524
  proteomes: 2535
  taxa: 4636
  structures: 2
  alphafold_models: 3059
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007460
description: BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like
  fold. The antitoxin that neutralises this toxin is [pfam:PF14384]. BrnT is found in bacteria, archaea,
  bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression,
  which is induced by a number of different environmental stresses. Expression of BrnT alone results in
  cessation of bacterial growth which can be rescued after subsequent expression of BrnA [[cite:PUB00058380]].