id: Pfam:PF04375
pfam_id: PF04375
name: HemX, putative uroporphyrinogen-III C-methyltransferase
short_name: HemX
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04375
counters:
  proteins: 3821
  matches: 3875
  proteomes: 3792
  taxa: 5052
  structures: 0
  alphafold_models: 2341
  domain_architectures: 15
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007470
description: This is a family of bacterial putative uroporphyrinogen-III C-methyltransferase proteins.
  It forms one of the members of a complex of proteins involved in the biogenesis of the inner membrane
  in E.coli. Uroporphorphyrin-III C-methyltransferase (HemX) is a single spanning inner membrane protein
  that regulates the activity of NAD(P)H:glutamyl-tRNA reductase (HemA) in the tetrapyrrole biosynthesis
  pathway [[cite:PUB00009969],[cite:PUB00054976]].