id: Pfam:PF04378
pfam_id: PF04378
name: Ribosomal RNA large subunit methyltransferase D, RlmJ
short_name: RsmJ
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04378
counters:
  proteins: 5989
  matches: 6029
  proteomes: 5836
  taxa: 7838
  structures: 10
  alphafold_models: 3804
  domain_architectures: 52
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007473
description: RlmJ is ribosomal RNA large subunit methyltransferase J is required for full methylation
  of 23S ribosomal RNA (rRNA) during ribosome biogenesis. The ribosomal RNA of E. coli carries 24 residues
  that require methylation, and this methyltransferase is the last to be described, that modifies A2030
  [[cite:PUB00068648]]. RlmJ displays a variant of the Rossmann-like methyltransferase (MTase) fold with
  an inserted helical subdomain. On binding cofactor and substrate a large shift of the N-terminal motif
  X tail is induced in order to make it cover the cofactor-binding site and to trigger active-site changes
  in motifs IV and VIII [[cite:PUB00068650]].