id: Pfam:PF04379
pfam_id: PF04379
name: ApaG domain
short_name: DUF525
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04379
counters:
  proteins: 11744
  matches: 11776
  proteomes: 9065
  taxa: 15356
  structures: 9
  alphafold_models: 8600
  domain_architectures: 67
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007474
description: The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic
  F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The
  domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The
  Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux.
  Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain
  may be involved in protein-protein interactions which could be implicated in substrate-specificity [[cite:PUB00009972],[cite:PUB00016988],[cite:PUB00018539],[cite:PUB00016989]].