id: Pfam:PF04380
pfam_id: PF04380
name: Membrane fusogenic activity
short_name: BMFP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04380
counters:
  proteins: 6218
  matches: 6218
  proteomes: 6209
  taxa: 8371
  structures: 0
  alphafold_models: 4101
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007475
description: BMFP consists of two structural domains, a coiled-coil C-terminal domain via which the protein
  self-associates as a trimer, and an N-terminal domain disordered at neutral pH but adopting an amphipathic
  alpha-helical structure in the presence of phospholipid vesicles, high ionic strength, acidic pH or
  SDS. BMFP interacts with phospholipid vesicles though the predicted amphipathic alpha-helix induced
  in the N-terminal half of the protein and promotes aggregation and fusion of vesicles in vitro.