id: Pfam:PF04384
pfam_id: PF04384
name: Iron-sulphur cluster assembly
short_name: Fe-S_assembly
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04384
counters:
  proteins: 2957
  matches: 2957
  proteomes: 2947
  taxa: 4104
  structures: 2
  alphafold_models: 1979
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007479
description: This family of proteins is likely to be involved in the assembly of iron-sulphur clusters.
  It may function as an adaptor protein. In Escherichia coli [swissprot:P0C0L9] forms part of the isc
  operon, which encodes genes involved in iron-sulphur cluster assembly. Its structure is entirely alpha
  helical, and it contains a modified wing-helix structure, usually found in DNA-binding proteins. It
  binds to Fe2+ and Fe3+ ions and to the cysteine desulfurase IscS, the same surface of the protein is
  involved in both binding to iron and to IscS [[cite:PUB00035643],[cite:PUB00054897]].