id: Pfam:PF04402
pfam_id: PF04402
name: Protein of unknown function (DUF541)
short_name: SIMPL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04402
counters:
  proteins: 16767
  matches: 16828
  proteomes: 13193
  taxa: 20114
  structures: 3
  alphafold_models: 10934
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007497
description: Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries.
  However possible family members have also been identified in translated rat (Genbank:AW144450) and human
  (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates
  with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between
  IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes,
  and thus regulate NF-kappa-B activity [[cite:PUB00010115]]. Separate experiments demonstrate that a
  mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is
  a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved
  in signal transduction and in the regulation of microtubule dynamics [[cite:PUB00009982]]. In bacteria
  its function is unknown, but it is thought to be located in the periplasm or outer membrane.