id: Pfam:PF04414
pfam_id: PF04414
name: D-aminoacyl-tRNA deacylase
short_name: tRNA_deacylase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04414
counters:
  proteins: 1386
  matches: 1417
  proteomes: 958
  taxa: 2187
  structures: 2
  alphafold_models: 1204
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007508
description: Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino
  acid onto their cognate tRNA. D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide
  and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive
  tRNA molecules.