id: Pfam:PF04440
pfam_id: PF04440
name: Dysbindin (Dystrobrevin binding protein 1)
short_name: Dysbindin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04440
counters:
  proteins: 3277
  matches: 3296
  proteomes: 761
  taxa: 2313
  structures: 0
  alphafold_models: 2940
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007531
description: Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to
  alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated
  with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localises with alpha-dystrobrevin
  at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found
  primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals
  in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne
  muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the
  muscle membrane [[cite:PUB00014974]]. Genetic variation in the human dysbindin gene is also thought
  to be associated with Schizophrenia [[cite:PUB00019482]].