id: Pfam:PF04447
pfam_id: PF04447
name: dATP/dGTP pyrophosphohydrolase
short_name: dATP-dGTP_PPHyd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04447
counters:
  proteins: 202
  matches: 204
  proteomes: 188
  taxa: 506
  structures: 1
  alphafold_models: 83
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007538
description: This domain is found in phage proteins, such as A0A2H5BHG5 from Acinetobacter phage SH-Ab
  15497, which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z),
  a DNA modification that gives phages an advantage for evading host restriction enzymes activity [[cite:PUB00097959]].
  This domain has dATP and dGTP pyrophosphohydrolase activity; it catalyses the hydrolysis of dATP/dGTP
  to pyrophosphate and dAMP/dGMP, respectively, with little or no activities for NTPs and pyrimidine dNTPs.
  It is suggested that enzymes containing this domain supply dGMP as the substrate for PurZ, elevating
  dZTP level to promote Z incorporation [[cite:PUB00097959]].