id: Pfam:PF04535
pfam_id: PF04535
name: Casparian strip membrane protein domain
short_name: CASP_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04535
counters:
  proteins: 17754
  matches: 18024
  proteomes: 388
  taxa: 1108
  structures: 0
  alphafold_models: 14486
  domain_architectures: 223
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006702
description: This domain is found mainly in plant proteins known as Casparian strip membrane proteins
  (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition
  of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly,
  the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking
  Casparian strips [[cite:PUB00088572],[cite:PUB00072979]].