id: Pfam:PF04547
pfam_id: PF04547
name: Calcium-activated chloride channel
short_name: Anoctamin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04547
counters:
  proteins: 24367
  matches: 25823
  proteomes: 3289
  taxa: 8741
  structures: 78
  alphafold_models: 20769
  domain_architectures: 348
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR049452
description: The family carries eight putative transmembrane domains, and, although it has no similarity
  to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in
  various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride
  currents in diverse physiological processes [[cite:PUB00069342]].