id: Pfam:PF04641
pfam_id: PF04641
name: Rtf2 RING-finger
short_name: Rtf2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04641
counters:
  proteins: 5475
  matches: 5538
  proteomes: 3338
  taxa: 8851
  structures: 0
  alphafold_models: 4684
  domain_architectures: 92
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
description: It is vital for effective cell-replication that replication is not stalled at any point by,
  for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork
  stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion
  of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates
  replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal
  direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif,
  and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+
  ion-binding site [[cite:PUB00066779]]. This domain is also found at the N-terminus of peptidyl-prolyl
  cis-trans isomerase 4, a divergent cyclophilin family [[cite:PUB00062056]].