id: Pfam:PF04672
pfam_id: PF04672
name: S-adenosyl methyltransferase
short_name: Methyltransf_19
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04672
counters:
  proteins: 17491
  matches: 17521
  proteomes: 1897
  taxa: 2351
  structures: 3
  alphafold_models: 9288
  domain_architectures: 36
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006764
description: This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet
  with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from [swissprot:Q82L35]
  suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was
  found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22
  . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).