id: Pfam:PF04720
pfam_id: PF04720
name: PDDEXK-like family of unknown function
short_name: PDDEXK_6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04720
counters:
  proteins: 6363
  matches: 6430
  proteomes: 428
  taxa: 1179
  structures: 0
  alphafold_models: 5140
  domain_architectures: 86
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006502
description: PDDEXK_6 is a family of plant proteins that are distant homologues of the PD-(D/E)XK nuclease
  superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteristic
  PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where
  x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue
  in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix
  [[cite:PUB00044133]]. The family is not in general fused with any other domains, so its function cannot
  be predicted [[cite:PUB00075365]].