id: Pfam:PF04721
pfam_id: PF04721
name: PNGase C-terminal domain, mannose-binding module PAW
short_name: PAW
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04721
counters:
  proteins: 1623
  matches: 1671
  proteomes: 991
  taxa: 3432
  structures: 3
  alphafold_models: 1367
  domain_architectures: 58
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006588
description: The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It
  was named for 'domain present in PNGases and other worm proteins' [[cite:PUB00011448]]. PNGase catalyses
  the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain
  before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form
  of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain,
  which contributes to the oligosaccharide-binding specificity of PNGase [[cite:PUB00041628]].