id: Pfam:PF04727
pfam_id: PF04727
name: ELMO/CED-12 family
short_name: ELMO_CED12
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04727
counters:
  proteins: 14425
  matches: 14729
  proteomes: 3212
  taxa: 8666
  structures: 15
  alphafold_models: 12473
  domain_architectures: 226
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006816
description: This family represents a conserved domain which is found in a number of eukaryotic proteins
  including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis
  and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required
  for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180
  as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously
  expressed, although its expression is highest in the spleen, an organ rich in immune cells [[cite:PUB00019508]].
  ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this
  alignment.