id: Pfam:PF04751
pfam_id: PF04751
name: Dual-action ribosomal maturation protein DarP
short_name: DarP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04751
counters:
  proteins: 4911
  matches: 4919
  proteomes: 4586
  taxa: 6784
  structures: 5
  alphafold_models: 3314
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006839
description: The entry, previously known as DUF615, represents the Dual-action ribosomal maturation protein
  DarP (also known as YjgA) from Escherichia coli and related proteins. This protein binds pre-50S ribosomal
  subunits near the 23S rRNA L1 stalk, where it probably mediate correct positioning of the L1 stalk [[cite:PUB00104166]].
  It plays a dual role in the late stages of assembly of the 50S ribosomal subunit where it promotes peptidyl
  transferase center maturation by modulating the docking of 23S rRNA helix H68, and maintains the stability
  of helix H89 with the help of uL16 (rplP), facilitating the final maturation of the peptidyl transferase
  center [[cite:PUB00155442]].