id: Pfam:PF05018
pfam_id: PF05018
name: CFA20 domain
short_name: CFA20_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05018
counters:
  proteins: 5992
  matches: 6394
  proteomes: 2195
  taxa: 6576
  structures: 28
  alphafold_models: 4438
  domain_architectures: 223
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007714
description: This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20
  is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and
  motility [[cite:PUB00072946],[cite:PUB00072975]]. In Chlamydomonas reinhardtii, it stabilises outer
  doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such
  as tektin and PACRG, to produce the beak structures in DMT1 [[cite:PUB00072975],[cite:PUB00072976]].
  Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N
  terminus, followed by a large C-terminal domain with multiple WD40 repeats [[cite:PUB00072975]]. This
  domain is also present in the N terminus of uncharacterised protein C3orf67.