id: Pfam:PF05050
pfam_id: PF05050
name: Methyltransferase FkbM domain
short_name: Methyltransf_21
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05050
counters:
  proteins: 21317
  matches: 21481
  proteomes: 8683
  taxa: 15058
  structures: 1
  alphafold_models: 14912
  domain_architectures: 576
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006342
description: This domain is characterised by two well-conserved short regions separated by a variable
  region in both sequence and length. Proteins containing this domain have been characterised as methyltransferases.
  FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant
  FK506 in Streptomyces strain MA6548 [[cite:PUB00009583]]. This domain is also found in other methyltransferases
  such as SdnD from the fungus Sordaria araneosa, involved in the biosynthesis of glycoside antibiotics
  with tetracyclic diterpene aglycone structure [[cite:PUB00089798]].