id: Pfam:PF05108
pfam_id: PF05108
name: Type VII secretion system ESX-1, transport TM domain B
short_name: T7SS_ESX1_EccB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05108
counters:
  proteins: 4566
  matches: 4744
  proteomes: 2423
  taxa: 2868
  structures: 19
  alphafold_models: 2663
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007795
description: EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type
  VII secretion system characterised in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent
  peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD,
  EccE, and MycP [[cite:PUB00083129],[cite:PUB00106938]]. EccB, EccC, EccD, and EccE form a stable complex
  in the mycobacterial cell envelope [[cite:PUB00083131]].