id: Pfam:PF05251
pfam_id: PF05251
name: Oligosaccharyltransferase subunit 5
short_name: Ost5
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05251
counters:
  proteins: 3042
  matches: 3052
  proteomes: 2536
  taxa: 7096
  structures: 12
  alphafold_models: 2628
  domain_architectures: 59
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007915
description: Eukaryotic N-glycosylation is catalysed in the ER lumen, where the enzyme oligosaccharyltransferase
  (OTase) transfers donor glycans from a dolichol pyrophosphate (DolP) carrier (Lipid-linked oligosaccharide;
  LLO) to polypeptides. The yeast OTase is a hetero-oligomeric complex composed of essential (Ost1, Ost2,
  Wbp1, Stt3, and Swp1) and nonessential (Ost3, Ost4, Ost5, and Ost6) subunits. This domain family is
  found in Ost5, [swissprot:Q92316]. The precise function of this subunit is not known, however Ost5 appears
  to form a sub-complex with Ost1, and this sub-complex associates with the catalytic Stt3 subunit of
  OTase. Down regulation of Ost5 resulted in a limited effect on glycosylation and no effect on the stability
  of Ost1 or Stt3 subunits [[cite:PUB00109240],[cite:PUB00109241]].