id: Pfam:PF05258
pfam_id: PF05258
name: Dna[CI] antecedent, DciA
short_name: DciA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05258
counters:
  proteins: 12811
  matches: 12812
  proteomes: 12625
  taxa: 17544
  structures: 2
  alphafold_models: 8175
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007922
description: This family contains several actinomycete proteins. Family members such as DciA (dna[CI]
  antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in
  Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional
  analysis revealed that DciA is essential for replication initiation and protein depletion resulted in
  a blockage of the initiation of replication after the formation of the open complex [[cite:PUB00085163]].