id: Pfam:PF05300
pfam_id: PF05300
name: MICOS complex subunit MIC19/MIC25
short_name: MIC19_MIC25
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05300
counters:
  proteins: 2697
  matches: 2774
  proteomes: 724
  taxa: 2240
  structures: 0
  alphafold_models: 2422
  domain_architectures: 18
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007964
description: MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS
  complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the
  maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the
  outer membrane [[cite:PUB00086469],[cite:PUB00086470],[cite:PUB00093460]]. MIC19 plays an important
  role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology [[cite:PUB00086469]].