id: Pfam:PF05341
pfam_id: PF05341
name: Per os infectivity factor 6
short_name: PIF6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05341
counters:
  proteins: 103
  matches: 103
  proteomes: 100
  taxa: 204
  structures: 0
  alphafold_models: 92
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008005
description: Family members include Autographa californica nuclear polyhedrosis virus (AcMNPV) Orf68 (also
  known as per os infectivity factor 6, PIF6 or ac68). PIF6 is present in both the budded virus (BV) and
  the occluded-derived virus (ODV). The ac68 gene overlaps the lef3 gene which encodes the single-stranded
  DNA binding protein, and knockout experiments of ac68 have to ensure that a functional lef3 gene is
  present. In ac68KO experiments, viral DNA replication and BV levels were unaffected as were mortality
  rates if caterpillars were injected with BV directly into the hemolymph bypassing the gut. However,
  in oral bioassays the ac68KO occlusion bodies failed to kill larvae, indicating that PIF6 is a per os
  infectivity factor [[cite:PUB00082605]].