id: Pfam:PF05346
pfam_id: PF05346
name: Eukaryotic membrane protein family
short_name: DUF747
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05346
counters:
  proteins: 4804
  matches: 4980
  proteomes: 3258
  taxa: 8637
  structures: 0
  alphafold_models: 4083
  domain_architectures: 84
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008010
description: This family is a family of eukaryotic membrane proteins. It was previously annotated as including
  a putative receptor for human cytomegalovirus gH [[cite:PUB00019476]] but this has has since been disputed
  [[cite:PUB00044752]]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation
  1) has shown it to be involved in patterning of the vertebrate axial skeleton.