id: Pfam:PF05551
pfam_id: PF05551
name: Zinc-binding loop region of homing endonuclease
short_name: zf-His_Me_endon
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05551
counters:
  proteins: 408
  matches: 426
  proteomes: 236
  taxa: 812
  structures: 46
  alphafold_models: 315
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008704
description: This domain [[cite:PUB00028315]] is the short zinc-binding loops region of a number of much
  longer chain homing endonucleases. Such loops are probably stabilised by the zinc and may be viewed
  as small but separate domains. The common structural feature of these domains is that at least three
  zinc ligands lie very close to each other in the sequence and are not incorporated into regular secondary
  structural elements. The biological roles played by these small zinc-binding domains are presently unknown
  [[cite:PUB00053732]].