id: Pfam:PF05600
pfam_id: PF05600
name: CDK5 regulatory subunit-associated protein 3
short_name: CDK5RAP3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05600
counters:
  proteins: 2603
  matches: 2827
  proteomes: 1694
  taxa: 5363
  structures: 5
  alphafold_models: 2226
  domain_architectures: 39
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008491
description: This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or
  LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling
  cell proliferation [[cite:PUB00086010],[cite:PUB00086014]]. It negatively regulates NF-kappa-B-mediated
  gene transcription through the control of RELA phosphorylation [[cite:PUB00043152],[cite:PUB00086011]].
  It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [[cite:PUB00086012],[cite:PUB00086013]].
  It has been shown to bind Wip1 and stimulates its phosphatase activity [[cite:PUB00086015]].