id: Pfam:PF05603
pfam_id: PF05603
name: Hikeshi-like, N-terminal domain
short_name: Hikeshi-like_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05603
counters:
  proteins: 3553
  matches: 3560
  proteomes: 3124
  taxa: 8350
  structures: 2
  alphafold_models: 3070
  domain_architectures: 60
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008493
description: This domain is found at the N-terminal end of Protein Hikeshi from humans and its orthologues
  OPI10 from other eukaryotes. Hikeshi is an specific nuclear import carrier for HSP70 proteins following
  heat-shock stress, which is required to protect cells from heat- shock damages. The N-terminal domain
  shows a jelly-roll/beta- sandwich fold with two layers of beta-sheets consisting of three and five and
  five antiparallel beta-strands [[cite:PUB00101203]].