id: Pfam:PF05608
pfam_id: PF05608
name: RTE1-like
short_name: RTE1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05608
counters:
  proteins: 3287
  matches: 3707
  proteomes: 1749
  taxa: 5517
  structures: 0
  alphafold_models: 2837
  domain_architectures: 54
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008496
description: This entry, previously known as DUF778, represents RTE1 (REVERSION-TO-ETHYLENE SENSITIVITY1)
  from Arabidopsis thaliana. RTE1 is positive regulator of the ETR1 ethylene receptor, leading to negative
  regulation of ethylene responses.[[cite:PUB00092499],[cite:PUB00092500]]. This entry also includes Arabidopsis
  RTE1 homologue, RTH, which acts via RTE1 in regulating ethylene responses and signaling [[cite:PUB00092501]].
  This domain is also present in TMEM222 from animals which in humans plays a role in brain development
  and function and mutations result in autosomal recessive neurodevelopmental disorder. This domain has
  been identified as structurally similar to peptidase C97 domain ([pfam:PF05903]).