id: Pfam:PF05620
pfam_id: PF05620
name: SRP-independent targeting protein 2/TMEM208
short_name: TMEM208_SND2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05620
counters:
  proteins: 3823
  matches: 3893
  proteomes: 3211
  taxa: 8600
  structures: 0
  alphafold_models: 3288
  domain_architectures: 54
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008506
description: This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane
  protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [[cite:PUB00083911],[cite:PUB00083915]].
  SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [[cite:PUB00083911]].
  TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions [[cite:PUB00083915]].
  SND2 also known as Env10 in Saccharomyces cerevisiae, and its homologue as Mug69 in Schizosaccharomyces
  pombe. They were identified as proteins involved in vacuolar processing and morphology [[cite:PUB00066964]]
  and meiosis [[cite:PUB00044889]], respectively.