id: Pfam:PF05638
pfam_id: PF05638
name: Type VI secretion system effector, Hcp
short_name: T6SS_HCP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05638
counters:
  proteins: 7751
  matches: 7781
  proteomes: 3501
  taxa: 5255
  structures: 22
  alphafold_models: 4734
  domain_architectures: 36
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008514
description: HCP is a family of proteins which are expressed in up to 1000 copies in Gram-negative bacteria.
  Together these copies aggregate into a needle-like shaft or tube that will penetrate other bacteria
  via a puncturing protein attached to its head [[cite:PUB00075434]] being part of the type VI secretion
  system [[cite:PUB00155386],[cite:PUB00054686]]. Initially Hcp forms a hexameric structure with a central
  channel of 40 Angstroms. These hexamers pile up one on top of each other forming nanotubes resembling
  the gp19 tail phage tube [[cite:PUB00034462]].