id: Pfam:PF05640
pfam_id: PF05640
name: Na,K-Atpase Interacting protein
short_name: NKAIN
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05640
counters:
  proteins: 4409
  matches: 4615
  proteomes: 1178
  taxa: 3872
  structures: 0
  alphafold_models: 3933
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008516
description: NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane
  proteins that localise to neurons, that are critical for neuronal function, and that interact with the
  beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved
  trans-membrane domains but otherwise no other characterised domains. NKAINs may function as subunits
  of pore or channel structures in neurons or they may affect the function of other membrane proteins.
  They are likely to function within the membrane bilayer [[cite:PUB00044756]].