id: Pfam:PF05647
pfam_id: PF05647
name: Tandem-repeating region of mucin, epiglycanin-like
short_name: Epiglycanin_TR
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05647
counters:
  proteins: 93
  matches: 302
  proteomes: 78
  taxa: 322
  structures: 0
  alphafold_models: 70
  domain_architectures: 12
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008519
description: The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region
  of this tandem-repeat at the N-terminus [[cite:PUB00066740]]. It was the first mucin identified to be
  associated with the malignant behaviour of carcinoma cells [[cite:PUB00066741]]. Mouse Muc21/epiglycanin
  is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent
  on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular
  matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21
  [[cite:PUB00066742]]. This family also now contains the repeat that was the C. elegans protein of unknown
  function (DUF801).