id: Pfam:PF05667
pfam_id: PF05667
name: CCDC22 protein coiled-coil region
short_name: CCDC22_CC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05667
counters:
  proteins: 1802
  matches: 1924
  proteomes: 1233
  taxa: 4130
  structures: 4
  alphafold_models: 1532
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR048348
description: Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B
  signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase
  complex [[cite:PUB00077065]]. It is part of the COMMD/CCDC22/CCDC93 (CCC) complex, which interacts with
  the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in
  conjunction with the retromer [[cite:PUB00077066]]. This entry also includes CCDC22 homologues from
  animals and plants.