id: Pfam:PF05670
pfam_id: PF05670
name: NFACT protein RNA binding domain
short_name: NFACT-R_1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05670
counters:
  proteins: 13115
  matches: 13157
  proteomes: 8466
  taxa: 17368
  structures: 20
  alphafold_models: 10207
  domain_architectures: 128
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008532
description: 'This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding
  protein by similarity. This annotation comes from [swissprot:O34693] where the N-terminal region is
  involved in this activity [[cite:PUB00011315]]. It is an RNA binding domain of the NFACT (NEMF, FbpA,
  Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to
  the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway
  which contributes to CAT-tailing and as a standalone domain [[cite:PUB00091027]]. Additionally this
  domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.'