id: Pfam:PF05685
pfam_id: PF05685
name: Putative restriction endonuclease
short_name: Uma2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05685
counters:
  proteins: 35097
  matches: 35117
  proteomes: 4365
  taxa: 6843
  structures: 4
  alphafold_models: 20569
  domain_architectures: 59
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008538
description: This entry includes a group of putative nuclease, including hypothetical protein TT1808 (also
  known as Uma2 or TTHA1514), an AT-rich DNA-binding protein from Thermus thermophilus. This domain has
  a 3-layer alpha/beta/alpha topology similar to that found in restriction endonucleases [[cite:PUB00035698]].
  The nuclease domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly
  in nucleases with diverse biological functions [[cite:PUB00035699]].