id: Pfam:PF05689
pfam_id: PF05689
name: Adhesion domain
short_name: InvE_AD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05689
counters:
  proteins: 199
  matches: 412
  proteomes: 130
  taxa: 225
  structures: 1
  alphafold_models: 86
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008541
description: This entry represents the Adhesion domain found in InvasinE (invE). Invasins are members
  of the inverse autotransporter (IAT) family also referred to as type Ve secretion system. In general,
  they consist of an N-terminal beta-barrel-like domain, which is responsible for attachment of invasin
  to the outer membrane region of bacteria, repetitive Immunoglobulin-like (Ig) domains, which vary significantly
  in number among all the invasins, and the C-terminal domain/adhesion domain (AD), which provides invasins
  with the specificity to bind to its host target molecules. InvE-AD adopts a C-type lectin-like domain
  (CTLD)fold with unique modifications. The core structure of the adhesion domain (AD) is made up of a
  globular alpha/beta fold and can be divided into three sub-sections. The first is a lasso-shaped loop
  structure termed the "adaptor ring" since it forms a ring-shaped platform that connects BIg21 [pfam:PF05688]
  with the two residual sub-sections in the AD. These two residual subsections are the "C-type lectin-like
  domain" and the "wedge module". InvE-CTLD lacks the ability to coordinate Ca2+, and motifs such as EPN,
  QPD, and WND that are responsible for the specificity of carbohydrate recognition are also absent, giving
  rise to the notion that the InvE-CTLD is not a carbohydrate binding domain [[cite:PUB00101290]].