id: Pfam:PF05708
pfam_id: PF05708
name: Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
short_name: Peptidase_C92
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05708
counters:
  proteins: 3259
  matches: 3260
  proteomes: 2690
  taxa: 4781
  structures: 2
  alphafold_models: 2152
  domain_architectures: 32
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024453
description: Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for
  the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each
  monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet
  that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, PDB:3kw0, is
  located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute
  to the formation of the active site, where the lysine ligand is bound [[cite:PUB00075488]].