id: Pfam:PF05768
pfam_id: PF05768
name: Glutaredoxin-like domain (DUF836)
short_name: Glrx-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05768
counters:
  proteins: 10668
  matches: 10669
  proteomes: 10193
  taxa: 16954
  structures: 6
  alphafold_models: 7176
  domain_architectures: 53
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008554
description: These proteins are related to the [pfam:PF00462] family. This entry includes several viral
  glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised
  member is G4L ([swissprot:P68460]) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is
  necessary for virion morphogenesis and replication [[cite:PUB00020627]]. This is a cytoplasmic protein
  which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [[cite:PUB00020628]].