id: Pfam:PF05769
pfam_id: PF05769
name: SIKE family
short_name: SIKE
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05769
counters:
  proteins: 2933
  matches: 3127
  proteomes: 1606
  taxa: 5060
  structures: 3
  alphafold_models: 2613
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008555
description: This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological
  suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered
  activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic
  antigen (CCA), found in Schistosoma mansoni (Blood fluke) [[cite:PUB00011317],[cite:PUB00059263]], and
  FGFR1 oncogene partner 2, which may be involved in wound healing pathway [[cite:PUB00059262]].