id: Pfam:PF05838
pfam_id: PF05838
name: Glycosyl hydrolase 108
short_name: Glyco_hydro_108
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05838
counters:
  proteins: 2895
  matches: 2895
  proteomes: 2293
  taxa: 4020
  structures: 6
  alphafold_models: 1838
  domain_architectures: 35
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008565
description: This family acts as a lysozyme (N-acetylmuramidase), [ec:3.2.1.17]. It contains a conserved
  EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity
  [[cite:PUB00109141]]. In bacteria, it may activate the secretion of large proteins via the breaking
  and rearrangement of the peptidoglycan layer during secretion [[cite:PUB00021044],[cite:PUB00109142]].
  It is frequently found at the N-terminus of proteins containing a C-terminal [pfam:PF09374] domain.