id: Pfam:PF05853
pfam_id: PF05853
name: beta-keto acid cleavage enzyme
short_name: BKACE
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF05853
counters:
  proteins: 11546
  matches: 11865
  proteomes: 6039
  taxa: 8565
  structures: 25
  alphafold_models: 7293
  domain_architectures: 34
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR008567
description: BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances
  it catalyses the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA
  [[cite:PUB00056558]]. The family is found to have at least 14 slightly different potential new enzymatic
  activities, all of which can therefore be designated as beta-keto acid cleavage enzymes [[cite:PUB00103502]].